In a small Indian Village Mandwa, Vijay Dinanath Chauhan (Hritik Roshan) is taught about the path of fire (Agneepath) by his principled father. His life is shattered completeley when the evil drug lord Kancha Cheena (Sanjay Dutt) hangs his father to death, Vijay leaves for Bombay with his pregnant mother, and takes an oath that he will return back to Mandwa and bring back the glory of his fathers name and take revenge against Kancha Cheena.

In Bombay, Vijay is taken under the wings of the cities drug lord Rauf Lala (Rishi Kapoor). From here on it is a journey of revenge where he makes and breaks many relationships only to get closer to his aim. Vijay finds support in his only friend Kaali (Priyanka Chopra), who stands by him at every moment of his life. Fifteen years later, his hatred for Kancha takes him back to Mandwa where life comes full circle.